Neonatal Diarrhoea – a challenge for pig farms worldwide:



1. ND occurs during the first days of a piglet’s life

2. The economic impact by ND with mortality of 10 % can be as high as 134 € per sow per year (Sjolund et al., 2014)

3. The aetiology is multifactorial

  • Enterotoxigenic E. coli (ETEC) expressing F4, F5 and F6 fimbrial adhesins
  • Clostridium perfringens Type A expressing alpha and beta2 toxin
  • Clostridium perfringens Type C expressing beta1 toxin are the major pathogens

4. Management plays a key role

  • to keep gilts and sows healthy and in good condition, to avoid outbreaks of other infectious diseases like Influenza or to control MMA
  • to boost the antibodies in gilts and sows colostrum by vaccination
  • to guarantee newly born piglets ideal environmental conditions and constantly undisturbed suckling during the most sensitive few days after birth

ENTEROPORC COLI AC - induces protective antibody titers:

Comparison of mean, protective antibody titers in colostrum of vaccinated gilts following basic (2fold) and sows (3rd) re-vaccination.

Mortality (E. coli) and morbidity (C. perfringens) were used as parameters of protection and to determine  ---- the protective titers for all antigens using a standardized procedure (ROC analysis, Youden-Index, which provides optimal ratio between specificity and sensitivity).

ENTEROPORC COLI AC – boosts antibodies after re-vaccination:


Percentage of gilts/sows with antibody titers in colostrum equal to or above
the protective titer

The efficacy of a third vaccination with ENTEROPORC COLI AC in sows administered 2 weeks before the second farrowing under field conditions was assessed by antibody titers and compared with the titers of gilts vaccinated twice (basic immunization). Antibodies either reached the same level or were even boosted.

ENTEROPORC COLI AC – is safe for sows and gilts:


Aluminium hydroxide-based adjuvant: long lasting immunity, induction of high IgG titers, excellent safety profile

The mean rectal body temperature of the vaccinates peaked 6 h post second vaccination with increase of 0.25°C and returned to normal within 24 hours.

A slightly depressed behaviour on the day of vaccination was recorded very commonly in the 3 field studies for registration. A slight redness and slight swelling at the injection site was observed very commonly which resolved within a week post administration. There was no significant difference between the treatment groups for any reproductive performance variable.

The mean rectal body temperature of the animals in both groups was slightly increased after vaccination, however remained at all time points within the physiological range.

ENTEROPORC COLI AC – broadest protection against Neonatal Diarrhoea:

with seven E. coli and Clostridia antigens in one vaccine including C. perfringens Type A, α and β2 toxoid           


  •  reduces mortality and morbidity
  •  ensures more and thriving piglets weaned
  •  saves time and effort

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