Respiporc® FLU Pan is protective against pandemic influenza strains in the field

Respiporc Flu Pan vaccination significantly reduces the viral load in the lungs¹

¹16 54-day-old pigs (OOI) and 19 53-day-old pigs (DOI) per group respectively were aerosol challenged with the strain FLUAV/sw/Schallern/IDT19989/2014 panH1N1. Pigs vaccinated twice with Respiporc FLUPAN H1N1 on day 54 (53) and day 85 (84), and non-vaccinated pigs were compared. The pigs were assigned to each of the groups in similar numbers and challenged either 7 days (OOI) or 3 months (DOI) after the vaccinated pigs got their second vaccination with Respiporc FLUPAN H1N1. A part of the pigs were euthanised on day 1 and another part on day 3. The virus lung load was determined with the tissue culture infectious dose 50 (TCID50) by titrating lung tissue homogenate in cell culture. The resulting virus load was calculated for 1 g lung tissue used for isolation.

Respiporc Flu Pan vaccination significantly reduces the virus excretion²

Respiporc Flu Pan vaccination significantly increases the production of serum neutralizing antibodies²

²In total the study included 39 pigs 53 – 55 days old. 19 pigs received vaccination with Respiporc FLUPAN H1N1 and a second vaccination 3 weeks later. The non-vaccinated group contained 20 pigs. Seven days after the second administration of the vaccine the challenge was conducted with a heterologous pandemic H1N1 strain FLUAV/sw/Teo(Spain)/AR641/2016 panH1N1. Virus shedding followed a marked pattern. Vaccinated pigs shed significantly less virus in comparison to unvaccinated ones on study days 1 – 3. After infection antibodies raised to very high titres. Unvaccinated pigs were found seronegative at the time of challenge and developed less pronounced antibody titres after infection.2, 3 Challenge trials from the registration dossier of Respiporc FLU PAN H1N1: 2TV 001/15 (OOI, 7 days) and TV 242/14 (DOI, 3 months) and 3TV 158/16 (Field/OOI2) respectivelyPesch et al., Development of a monovalent pig vaccine based on a human pandemic H1N1 (2009) strain, ESPHM 2018, Barcelona

Respiporc® Flu Pan improves reproduction data significantly

 

Reproductive performance in sow herds infected with pandemic influenza A virus was evaluated before and after implementation of the vaccination with Respiporc® FLU pan³.

³Gumbert et al. Porcine Health ­Management (2020) 6:4 https://doi.org/10.1186/s40813-019-0141-x

Sows are protected during the whole reproduction cycle, during pregnancy, suckling period and mating.

Breeding farms experience a positive return on investment (ROI): 
1.33 extra piglets weaned per sow per year pays back 5.11 times the cost of the yearly vaccine treatment (considering 3 vaccinations in sows and 2 in gilts).
Considering that 1 time pays back the vaccine, the other 4.11 times are benefit. 
This represents € 28,000 per year in a 1000-sow farm (based on costs of production, not market price).

Source: economical calculator of SIP Consultors, Barcelona, Spain

Respiporc® Flu Pan H1N1 vaccination schedule

Vaccination of pigs from the 56th day of life.