Coglapix® Editions

Inactivated vaccine against swine pleuropeumonia caused by Actinobacillus pleuropeumoniae

Two years Field trial

The  study was conducted in a Spanish farrow-to-finish farm with a 1,700-sow
capacity, The investigation was carried out over a period of two years. This extended timespan helped to equalise and remove seasonal biases such as climatic variations, as well as differences between years, like potential variations in the mycotoxin levels contained in animal feed.

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COGLAPIX efficacy field trial

Supervised by Prof. Dr. Paolo Martelli Full Professor of Internal Medicine, Department of Veterinary Sciences, University of Parma, Director of the Residency programme of the ECPHM - University of Parma.
The aim of this study was to assess the efficacy of Coglapix® in reducing mortality, morbidity measured as lung lesions and individual treatments, and potential economic benefits by preventing A.p. outbreak and disease over an extended rearing period in an A.p. endemic farm with recurrent outbreaks amongst finishers.

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Coglapix contributes to the rational use of antimicrobials 

A field trial performed with Coglapix® in The Netherlands is described in a farm presenting Actinobacillus pleuropneumoniae infection.

Using a veterinary application, “VetApp”, which has been developed to follow-up the health status on pig farms during the monthly farm visits, a reduction of the coughing index has been associated with a drop of mortality by approximately 50% and the antibiotic use was reduced to almost zero after the introduction of the vaccine.

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Coglapix efficacy against heterologous serotypes of A.pleuropneumoniae

The distribution of various serotypes of Actinobacillus pleuropneumoniae differs substantially among countries.

The presence of various serotypes in a farm as well as in a given area doesn’t stay stable, but evolves over the time.

Serotype 8 is the most prevalent in the UK and was isolated also in other countries as highly virulent. In an experimental challenge trial, Coglapix® documented high efficacy against the serotype 8 of A. pleuropneumoniae.

There was the lowest rate of clinical symptoms and no mortality in pigs vaccinated with Coglapix®.

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Interest of lung scorring together with serological profiling of the herd 

Lung scoring together with serological profiling of the herd is a useful approach to assess prevalence and severity of some important respiratory pathogens and determine a most efficient vaccination program.

Dr Andrea Luppi from Izsler Institute is sharing the main conclusion of a large epidemiological study performed in Italy. This study demonstrates that:

 the Enzootic Pneumonia (EP)-like lesions average values show significant associations with the intra herd seroprevalence for M.hyo at 18 weeks of age, confirming a good correlation between the EP like lesions recorded at the slaughter house and previous M.hyo infection.

 Dorso-caudal pleurisy average value and Actinobacilluspleuropneumonaie index (API) are significantly associated to A.p herd seroprevalence.

 These evaluations confirm once again the importance of the scoring of the lungs at the slaughterhouse, in order to discover pleural lesions due to sub-clinical cases and bronchopneumonia lesions, otherwise often under estimated…

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How to use currently available diagnostic tools 

Professor Marcelo Gottschalk from the University of Montreal is sharing the main available tools to help diagnosing the porcine pleuropneumonia disease in its different forms.

 The diagnosis of the subclinical forms of porcine pleuropneumonia is complicated. Serology against all serotypes of App (based on Apx IV toxin-based ELISA) can be performed. First, samples at the slaughter house can be taken (between 25 and 30 serum samples).
 In presence of clinical signs, the identification of the serotype after isolation, serological tests or more specific tests (PCR) can be performed to indicate or not the presence of a highly virulent serotype, and help control the spread of infection in the herd.
 Moreover, Pr Gottschalk explains that it would be extremely dangerous to establish a correlation between the antibodies detected by commercial kits and protection of vaccinated animals. 

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Outcome from a respiratory diseases survey in Germany

Matthias eddicks PhD in vet medicine from the ludwig-Maximilians-university Munich highlighted throw this study the Ap serotype distribution and difference in the regional epidemiological situation, he explained also how lung scoring combined to serology could be a relevent diagnostic for monitoring respiratory pathogens both Ap & M.hyo in the farms.

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From one country to another, product lines are adapted to local demand and regulatory requirements. For further information, please take a look at the CEVA Santé Animale site for your country. Warning: the information provided on the products depends on national registrations. Access to technical information is restricted to authorised persons.

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